The twin spans of the railway bridge crossing the River Thames between Little Stoke on the eastern bank to Moulsford on the western bank. It carries the Great Western Main Line from Paddington to Wales and the West. It lies between Goring & Streatley and Cholsey stations and crosses the Thames on the reach between Cleeve and Benson Locks.

The bridge was designed to carry two broad gauge tracks by Brunel for the Great Western Railway and was built between 1838 and 1839. It is constructed from red brick with Bath stone quoins as four elliptical skew arches of 62 feet (19 m).

Moulsford Railway Bridge from the South - Wallingford visitor guide showing a virtual tour of 'Moulsford Railway Bridge from the South' linked to an interactive map with local and travel information. 360° panoramas from Oxfordshire.